GLOW Peptide Blend

The concept of the GLOW Blend arises from decades of research into individual signaling peptides. GHK-Cu was first identified in biological plasma samples in the 1970s and later studied for gene regulation and matrix remodeling activity. BPC-157 was synthesized in the 1990s as a gastric protein fragment analog and has since been researched for angiogenic and structural processes. TB-500, the synthetic thymosin beta-4 sequence, traces its research lineage to thymus peptide studies in the 1960s and is recognized for its effects on molecular migration and angiogenesis. Combined, these peptides represent a convergence of experimental research lines.

CAS #: 89030-95-5
Molecular Formula: C₁₄H₂₃CuN₆O₄⁺
Molecular Weight: 402.92 g/mol
PubChem ID: 71587328

CAS #: 137525-51-0
Molecular Formula: C₆₂H₉₈N₁₆O₂₂
Molecular Weight: 1419.5 g/mol
PubChem ID: 9941957

CAS #: 77591-33-4
Molecular Formula: C₂₁₂H₃₅₀N₅₆O₇₈S
Molecular Weight: 4963.5 g/mol

The individual constituents of the GLOW Blend — GHK-Cu, BPC-157, and TB-500 — have been studied separately in laboratory and preclinical research contexts, including structural, epithelial, vascular, and systemic models. That research has examined collagen organization, molecular migration, angiogenesis, and molecular signaling.

Key Areas of Research:

• Structural: Collagen, matrix, tendon/ligament
• Epithelial: Migration, matrix signaling, follicle dynamics
• Vascular: Angiogenesis, nitric oxide, formation
• Systemic: Signaling, viability, pathway dynamics

These findings relate to the individual constituents; the studies cited on this page did not examine the finished GLOW Blend.

Analytically, the three constituents differ substantially in size and class: GHK-Cu is a copper-coordinated tripeptide (402.92 g/mol), BPC-157 is a 15-amino-acid linear peptide (1419.5 g/mol), and TB-500 is listed at 4963.5 g/mol. These differences in molecular weight and composition are relevant to chromatographic separation and identity characterization of a multi-component formulation.

Pickart L. et al., 2015

Pickart L. et al. (2015). Biomed Res Int, 2015:648108. PubMed ID 26236730.

Maquart F.X. et al. (1988). Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. FEBS Lett, 238:343–6.

Japjec M. et al. (2021). Biomedicines, 9(11). PubMed ID 34829776.

Smart N. et al. (2007). Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization. Nature, 445(7124):177–82.

Hsieh M.J. et al. (2017). J Mol Med (Berl), 95(3):323–333. PubMed ID 27847966.

Bock-Marquette I. et al. (2004). Nature, 432(7016):466–72. PubMed ID 15565145.