Certificate of Analysis
Independent analysis of this lot by Kovera Labs (HPLC-UV).
- Purity
- 99.21%
- Lot
- ML-260916
- Tested Most recent
- Sep 2026
MOTS-c Peptide
In Stock- CAS
- 1627580-64-6
- Molecular weight
- 2174.6 g/mol
- Form
- Lyophilized powder
- Purity (HPLC)
- 99.21% HPLC-UV
- Storage
- -20°C or colder
- Lot / COA
- Free shippingOn every order
- Free 2nd Day AirOn orders $200+
Research Use Only
For laboratory research use only. Not for human consumption. All products are intended solely for laboratory research and are not for human or animal consumption. By purchasing, the buyer agrees to use these products in compliance with all applicable laws.
Specifications
- CAS
- 1627580-64-6
- Molecular formula
- C101H152N28O22S2
- Molecular weight
- 2174.6 g/mol
- Form
- Lyophilized powder
- Purity (HPLC)
- 99.21% HPLC-UV
- Storage
- -20°C or colder
- Lot / COA
- PubChem CID
- 146675088
Certificate of Analysis
Independent analysis of this lot by Kovera Labs (HPLC-UV).
- Purity
- 99.21%
- Lot
- ML-260916
- Tested Most recent
- Sep 2026
MOTS-c Peptide Overview
MOTS-c (sometimes written MOTS c) is a 16-amino-acid mitochondrial-derived peptide encoded by a short open reading frame within the mitochondrial 12S rRNA gene. The MOTS-c peptide has been studied in cellular and experimental models for its relationship with AMPK-associated signaling, metabolic regulation, and adaptive responses to metabolic stress.
NAD+ is a related mitochondrial and bioenergetic research material in the Medicina Labs catalog.
For the mitochondrial-derived peptide classification, see What Is MOTS-c?
History
MOTS-c was first described in 2015 following the discovery of short open reading frames encoded within mitochondrial DNA. Identified as a mitochondrial-derived peptide with signaling activity, it has since been studied for its ability to activate AMPK pathways and for its nuclear translocation under conditions of cellular stress. This discovery expanded the understanding of mitochondria as signaling organelles beyond energy production, positioning MOTS-c as a key peptide in mitochondrial biology research.
MOTS-c Structure
CAS #: 1627580-64-6
Molecular Formula: C101H152N28O22S2
Molecular Weight: 2174.6 g/mol
PubChem ID: 146675088
Research Findings
MOTS-c has been studied in mitochondrial, molecular, and systemic models, with research highlighting its role in mitochondrial function, AMPK pathway activation, and signaling dynamics. Studies also report activity in substrate utilization, downstream markers, and molecular stress responses in preclinical settings.
Key Areas of Research:
- Mitochondrial: AMPK, signaling, pathway dynamics
- Molecular: Mitochondrial function, stress response, remodeling
- Systemic: Signaling, nuclear translocation, viability
Together, these findings suggest broad experimental potential for MOTS-c across mitochondrial, molecular, and systemic pathways. By engaging mitochondrial biology and modulating AMPK and stress response pathways, MOTS-c provides a versatile platform for research into pathway characterization, molecular dynamics, and mitochondrial–nuclear communication in laboratory settings.
Our Process
Precision Lyophilization
Each batch is freeze-dried and sealed for stability until reconstitution.
Verified Purity
Every batch is third-party tested with HPLC and mass spectrometry.
Careful Fulfillment
Orders ship within 24 hours from our U.S. facility.