KLOW Peptide Blend

The KLOW Blend draws on several decades of peptide research. GHK-Cu, first identified in biological plasma samples in the 1970s, has been studied for gene expression and matrix signaling. BPC-157, synthesized in the 1990s as a gastric protein fragment analog, has been explored for angiogenic and structural processes. TB-500, the synthetic thymosin beta-4 sequence whose research lineage dates to the 1960s, has been examined for angiogenesis and molecular migration. KPV, a C-terminal fragment of α-MSH, has been evaluated for cytokine-modulating and immunomodulatory activity. Collectively, these peptides represent areas of ongoing investigation into experimental biology, vascular pathways, and immune signaling. The KLOW Blend is intended for research use only.

Maquart F.X. et al. 1988

CAS #: 89030-95-5
Molecular Formula: C₁₄H₂₃CuN₆O₄⁺
Molecular Weight: 402.92 g/mol
PubChem ID: 71587328

CAS #: 137525-51-0
Molecular Formula: C₆₂H₉₈N₁₆O₂₂
Molecular Weight: 1419.5 g/mol
PubChem ID: 9941957

CAS #: 77591-33-4
Molecular Formula: C₂₁₂H₃₅₀N₅₆O₇₈S
Molecular Weight: 4963.5 g/mol

CAS #: 67727-97-3
Molecular Formula: C₁₆H₃₀N₄O₄
Molecular Weight: 342.43 g/mol
PubChem ID: 125672

The individual constituents of the KLOW Blend — GHK-Cu, BPC-157, TB-500, and KPV — have been studied separately in laboratory and preclinical research contexts, including structural, vascular, epithelial, and systemic models. That research has examined collagen formation, extracellular matrix remodeling, angiogenesis, molecular migration, and cytokine modulation.

Key Areas of Research:

• Structural: Collagen, matrix, connective signaling
• Vascular: Angiogenesis, nitric oxide, remodeling
• Epithelial: Migration, matrix signaling, follicle dynamics
• Systemic: Cytokine modulation, immune signaling, pathway dynamics

These findings relate to the individual constituents; the studies cited on this page did not examine the finished KLOW Blend.

Analytically, the four constituents span two orders of magnitude in size: KPV is a Lys-Pro-Val tripeptide (342.43 g/mol), GHK-Cu is a copper-coordinated tripeptide (402.92 g/mol), BPC-157 is a 15-amino-acid linear peptide (1419.5 g/mol), and TB-500 is listed at 4963.5 g/mol. These differences in molecular weight and composition are relevant to chromatographic separation and identity characterization of a multi-component formulation.

Pickart L. et al. (2015). Biomed Res Int, 2015:648108. PubMed ID 26236730.

Maquart F.X. et al. (1988). Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. FEBS Lett, 238:343–6.

Japjec M. et al. (2021). Biomedicines, 9(11). PubMed ID 34829776.

Smart N. et al. (2007). Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization. Nature, 445(7124):177–82.

Seiwerth S. et al. (2018). Curr Pharm Des, 24(18):1972–1989. PubMed ID 29998800.

Hsieh M.J. et al. (2017). J Mol Med (Berl), 95(3):323–333. PubMed ID 27847966.